The CAPICE project PhD students from the United Kingdom presented their research studies at the World Conference of Psychiatric Genetics (WCPG) 2019, in Los Angeles, California, October 26-31, 2019. This article contains information about talks and a posters presented at the conference: talk "Multivariable G by E prediction of educational achievement in adolescence" by Andrea Giuseppe Allegrini; poster "A Mendelian Randomisation Study on Causality Between Attention-Deficit/Hyperactivity Disorder and Multiple Obesity-Related Traits" by Ville Karhunen.
The conference theme of 2019 was “Achieving Precision Psychiatry”.
Andrea Giuseppe Allegrini gave the talk on"Multivariable G by E prediction of educational achievement in adolescence".
Multivariable Prediction
• Environmental measures are heritable
• Polygenic scores partly capture environmental effects
• Implications for prediction?
GE correlation (rGE)
GE interaction (G*E)
Summary of the talk:
• Jointly modelling of E + G significantly improves prediction of EA
• rGE underlying variation in EA (rGE = .36)
38% of the G effects on EA mediated by E
18% of E effects on EA explained by G (confounding)
• 11 detected GxE interactions between GPS and environmental factors
• No evidence that GxE effects collectively played a role in multivariable prediction
Ville Karhunen presented the poster "A Mendelian Randomisation Study on Causality Between Attention-Deficit/Hyperactivity Disorder and Multiple Obesity-Related Traits".
